The Nobel Prize for Peripheral Immune Tolerance: What It Might Mean for Neurodiversity and Childhood Cancer
The Nobel Prize for Peripheral Immune Tolerance: What It Might Mean for Neurodiversity and Childhood Cancer A Nobel Moment for the Immune System The 2025 Nobel Prize in Physiology or Medicine went to Mary Brunkow , Fred Ramsdell , and Shimon Sakaguchi for their discoveries concerning peripheral immune tolerance — how the immune system restrains itself from attacking the body’s own tissues. Their work put a bright spotlight on regulatory T cells (Tregs) and the FOXP3 gene, the master regulator of Treg identity. First, to ground what was just awarded: The 2025 Nobel Prize in Physiology or Medicine went to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering mechanisms of peripheral immune tolerance — i.e. how the immune system keeps itself in check outside of the central (thymic / bone marrow) tolerance checkpoints. ( Nature ) A central factor in that discovery is the role of regulatory...