Is Paracetamol (APAP) Usage During Pregnancy a Cause of ADHD – Or Just a Proxy Marker For ADHD Susceptibility? Rethinking a Recent Nature Study Linking APAP to Neurodevelopmental Risk A recent study published in Nature Mental Health (June 2025) has reignited debate about whether acetaminophen (paracetamol or APAP) taken during pregnancy could contribute to the development of attention deficit hyperactivity disorder (ADHD) in children. Using maternal blood biomarkers rather than self-reported medication use, the researchers reported that prenatal APAP exposure was associated with a more than threefold increase in ADHD diagnosis rates in offspring. The study also found that children of mothers who had detectable APAP levels during the second trimester showed altered placental gene expression — notably, upregulation of immune system genes and downregulation of oxidative phosphorylation pathways . These changes were especially prominent in female offspring and were linked to increased...